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Acetylcysteine Drug (medication) Information

Because compatibility with other medications may vary between manufacturers of acetylcysteine, refer to individual manufacturer's guidelines before combining with other medications or solvents. If an admixture is prepared, administer as soon as possible after preparation. Do not store admixtures for future use.

How to Take Acetylcysteine

Take Acetylcysteine exactly as prescribed by health care provider. For inhalation or direct instillation into bronchial tree. Not for parenteral administration.Do not use nebulization equipment with Acetylcysteine that contains iron, copper, or rubber because of potential for corrosion. Use glass, plastic, aluminum, anodized aluminum, chromed metal, tantalum, sterling silver, or stainless steel equipment. Silver may become tarnished after exposure to acetylcysteine, but this is not harmful to the patient and does not reduce the effectiveness of the medication.

Dosage Instructions for Acetylcysteine Drug

Reduction of viscosity of bronchopulmonary mucous secretions in patients with chronic or acute lung diseases, pulmonary complications associated with cystic fibrosis, surgery, anesthesia, or atelectasis caused by mucous obstruction; diagnostic bronchial studies; tracheostomy care, posttraumatic chest conditions (oral solution); prevention or lessening of liver damage after potentially toxic quantity of acetaminophen (oral or IV).

Contraindications of Acetylcysteine

Hypersensitivity to sulfonylureas; diabetes complicated by ketoacidosis; sole therapy of insulin-dependent (type I) diabetes mellitus; diabetes complicated by pregnancy.

Interactions of Acetylcysteine with other drugs

Do not mix with tetracycline, chlortetracycline, oxytetracycline, erythromycin lactobionate, amphotericin B, ampicillin sodium, iodized oil, chymotrypsin, trypsin, or hydrogen peroxide.

What are the Side Effects of Acetylcysteine -

Like other medicines, Acetylcysteine can cause side effects. Some of the more common side effects of Acetylcysteine include

* Tachycardia, hypotension, hypertension, chest tightness (oral); tachycardia, chest tightness

* Drowsiness

* Rash, pruritus, angioedema (oral); pruritus, rash, flushing

* Rhinorrhea (oral); ear pain, pharyngitis, throat tightness

* Nausea, vomiting, stomatitis (oral); nausea, vomiting

* Bronchospasm, bronchial irritation (oral); rhinorrhea, rhonchi

* Fever, clamminess

Warnings and precautions before taking Acetylcysteine :

* Advise patient before using Acetylcysteine or caregiver to notify health care provider if any of the following occur: rash or other signs or allergic reaction, new or worsening wheezing, chest tightness or difficulty breathing, persistent nausea or vomiting, coughing up blood, fever, or other signs of respiratory infection.

* Advise patient before using Acetylcysteine or caregiver that administration using face mask may leave a sticky residue on the face that can be easily removed by washing with water.

* The safety and efficay of Acetylcysteine medicine have not been studied in children and adolescents.

* Instruct patient to call health care provider if any of the following symptoms occur: nausea, vomiting, heartburn, diarrhea, fever, sore throat, rash, itching, weakness, unusual bruising, bleeding.

* Advise patient before using Acetylcysteine or caregiver that medication has a disagreeable odor (rotten eggs) but that this should become unnoticeable after continued use.

* Advise women before using Acetylcysteine to inform health care provider if pregnant, planning to become pregnant, or breastfeeding while taking Acetylcysteine. Insulin is recommended to maintain blood glucose levels during pregnancy. Prolonged severe neonatal hypoglycemia can occur if sulfonylureas are administered at time of delivery.

What if Overdose of Acetylcysteine ?

If you think you or anyone else taken overdose of Acetylcysteine , immediately telephone your doctor or contact your local or regional Poisons Information Centre Seek medical attention immediately. You may need urgent medical attention. Advise patient, family, or caregiver that medication will be prepared and administered by a health care professional in a hospital setting.

What if Missed Dose of Acetylcysteine ?

If you miss a dose of Acetylcysteine medicine and you remember within an hour or so, take the dose immediately. If you do not remember until later, skip the dose you missed and go back to your regular schedule. Do not double doses.

Storage Conditions for Acetylcysteine :

Store unopened vials at controlled room temperature (68° to 77°F). Diluted solution is stable for up to 24 hr at controlled room temperature.

By: ashu

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Protecting Your Baby from Acid Reflux

Acid reflux, which is also termed as gastroesophageal reflux, is one of the most frequent problems among infants. Babies with acid reflux often suffer from a range of conditions, from a mild degree to a severe one, such as recurrent spitting up, abdominal pain, and night waking.

This discussion would be more comprehensive with the understanding of the physiological or the mechanical aspect of the condition. The body has a band of muscle in a circular structure that is called the lower esophageal sphincter. This muscle detaches the esophagus from the stomach. When food comes into the stomach, it closes so as to prevent the stomach acids and contents from backing up into the esophagus or regurgitating. But in the case of some babies, the lower esophageal sphincter has grown immature. As such, the partially digested food and digestive acids are allowed to be refluxed. This condition causes irritation in the esophagus lining which results to inflammation that is also commonly called as heartburn.

Acid reflux among babies usually develops when they are between two to four weeks old. Doctors usually prescribe medicines that minimize the production of digestive acids. Within six to nine months, the acid reflux starts to naturally subside. At this time period, the babies spend most of their time in an upright position. This is to apply the law of gravity on the food taken in; that is, the food stays down more naturally and reduces possible regurgitation.

The following are helpful pointers on feeding and positioning of babies to lessen acid reflux:

Prepare smaller feedings recurrently. It makes sense to feed your baby more than usual but less than the accustomed. If lesser volume of milk goes into the stomach, the digestion will be faster and there will be fewer amounts of contents available for regurgitation.

Maintain the baby in an upright position after feeding. As discussed earlier, gravity helps to keep the digestive contents down. Position your baby seated in your lap while his head rests on your chest. Keep this position for at least half an hour after feeding.

Breastfeeding helps a lot. Breast milk is well-known to have many advantages over other commercial formula, mainly for babies with acid reflux. Breast milk can be digested faster, which of course lessens spitting up, and it has special enzymes that assists digestion. In addition to that, breast milk does not trigger allergy to babies compared to other milks available in the market. But for those who are formula-feeding, it is advisable to use milk with a hypoallergenic formula as advised by a doctor. Aside from having higher tolerance with sensitive intestines, hypoallergenic milk can also be digested faster by the stomach so as to minimize refluxes.

Set your baby in a comfortable position when asleep. Since when a baby lies flat when sleeping, gravity cannot help in keeping the food down in this set-up. As a result, a baby with acid reflux often has to endure a sore night waking. If a baby can sleep soundly, then there will be no need to call for a change in his habit. But some babies become restless, which can be noted by abdominal pain, acid breath, and wet burps. In this case, it is recommended to elevate the baby's crib to about 30 degrees. This will be enough to reduce the regurgitation. You may also try to train him to sleep on his left side. It is in this position where the inlet of the stomach is higher than the exit. This will also help to keep the food down.

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